7th March 2016 – ICMR Research Seminar – Spring Term Series

Monday 7th March 2016 – ICMR Research Seminar – Spring Term Series- Harborne Lecture Theatre 1:00pm – 2:00pm. Refreshments and discussion will take place after the seminar in the Harborne foyer.

‘NO and redox signalling in the healthy and diseased myocardium’

speaker – Prof Barbara Casadei, University of Oxford.

Barbara Casadei is the British Heart Foundation Professor of Cardiovascular Medicine, Honorary Consultant Cardiologist at the Radcliffe Department of Medicine (RDM), University of Oxford. Prof Casadei’s work aims to understand nitric oxide (NO) and redox signalling in the healthy and diseased myocardium. Her group undertake preclinical studies using small molecules or gene transfer in large animal models of human disease, enabling crucial intermediate steps in the path leading to clinical translation of basic findings.
In collaboration with others her group have developed techniques for evaluating the cardiac electrophysiological phenotype of murine models of human disease (e.g., in vivo programmed electrical stimulation and optical mapping in isolated hearts) and in silico modelling in the context of human atrial fibrillation which has been used as an hypothesis-generating tool to dissect the ion channels and transporters involved in the changes in action potential duration and calcium handling that are evoked by the activity of oxidase systems in atrial myocytes isolated from patients with atrial fibrillation.
Prof Casadei group also have a strong focus on patient-based research comprising mechanistic in vivo and in vitro studies, prospective investigations in cohorts of patients and, more recently, clinical trials. All directed to the identification of biomarkers and therapeutic targets for the prediction and prevention of atrial fibrillation and other in-hospital complications in patients undergoing cardiac surgery and to studies of the role of NO released by the neuronal isoform of NO synthase in the regulation of vascular tone and arterial blood pressure in humans in vivo.



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